Body mass index and physical activity and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies.

ABSTRACT:

Purpose

We conducted a systematic review and meta-analysis of prospective studies of the association between body mass index (BMI) and physical activity and diverticular disease risk.

Methods

PubMed and Embase databases were searched up to February 7, 2017. Summary relative risks and 95% confidence intervals (95% CIs) were calculated using a random effects model and nonlinear associations were modeled using fractional polynomial models.

Results

Six cohort studies of BMI and diverticular disease risk (28,915 cases, 1,636,777 participants) and five cohort studies of physical activity and diverticular disease risk (2080 cases, 147,869 participants) were included. The summary relative risk (RR) of incident diverticular disease for a 5 unit BMI increment was 1.28 (95% CI:

SUBMITTER: Aune D 

PROVIDER: S-EPMC5682875 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature