Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors.

ABSTRACT: The centromere is a genomic locus required for the segregation of the chromosomes during cell division. This chromosomal region together with pericentromeres has been found to be susceptible to damage, and thus the perturbation of the centromere could lead to the development of aneuploidic events. Metabolic abnormalities that underlie the generation of cancer include inflammation, oxidative stress, cell cycle deregulation, and numerous others. The micronucleus assay, an early clinical marker of cancer, has been shown to provide a reliable measure of genotoxic damage that may signal cancer initiation. In the current review, we will discuss the events that lead to micronucleus formation and centromeric and pericentromeric chromatin instability, as well transcripts emanating from these region

SUBMITTER: Hernandez-Saavedra D 

PROVIDER: S-EPMC5683002 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature