Association between hippocampus volume and symptom profiles in obsessive-compulsive disorder.

ABSTRACT:

Background

The hippocampus has recently been identified to play a key role in the pathophysiology of adult obsessive-compulsive disorder (OCD). Surprisingly, there is only limited evidence regarding the potential relationships with symptom dimensions. Due to the heterogeneity of symptoms in OCD, we aimed at further examining, whether hippocampal volume differences might be related to symptom profiles instead of single symptom dimensions.

Methods

In order to find out more about the potential association between clinical symptom profiles and alterations in hippocampal volume we categorized a large sample of OCD patients (N = 66) into distinct symptom profile groups using K-means clustering. In addition, hippocampal volumes of the different symptom profile groups were co

SUBMITTER: Reess TJ 

PROVIDER: S-EPMC5683038 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature