Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.

ABSTRACT: Studies suggest that arteriolar pressure-induced vasoconstriction can be initiated by GPCRs (G protein-coupled receptors), including the AT₁R (angiotensin II type 1 receptor). This raises the question, are such mechanisms regulated by negative feedback? The present studies examined whether RGS (regulators of G protein signaling) proteins in vascular smooth muscle cells are colocalized with the AT₁R when activated by mechanical stress or angiotensin II and whether this modulates AT₁R-mediated vasoconstriction. To determine whether activation of the AT₁R recruits RGS5, an in situ proximity ligation assay was performed in primary cultures of cremaster muscle arteriolar vascular smooth muscle cells treated with angiotensin II or hypotonic solution in

SUBMITTER: Hong K 

PROVIDER: S-EPMC5683087 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature