Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers.

ABSTRACT:

Background

Prospective cohort studies of circulating sex steroid hormones and prostate cancer risk have not provided a consistent association, despite evidence from animal and clinical studies. However, studies using male pattern baldness as a proxy of early-life or cumulative androgen exposure have reported significant associations with aggressive and fatal prostate cancer risk. Given that androgens underlie the development of patterned hair loss and chest hair, we assessed whether these two dermatological characteristics were associated with circulating and intraprostatic concentrations of sex steroid hormones among men diagnosed with localized prostate cancer.

Methods

We included 248 prostate cancer patients from the NCI Prostate Tissue Study, who answered surveys and pro

SUBMITTER: Zhou CK 

PROVIDER: S-EPMC5683095 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature