In utero exposure to organochlorine pesticides and early menarche in the Avon Longitudinal Study of Parents and Children.

ABSTRACT:

Introduction

Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited.

Methods

Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5years of age (cases) and 230 girls who reported menarche at or after 11.5years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI.

Results

We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p'-DDT, p,p'-DDE, oxychlordane or trans-nonachlor and early menarche.

Conclusio

SUBMITTER: Namulanda G 

PROVIDER: S-EPMC5683171 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature