Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.

ABSTRACT: Effective adaptive immune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly identifying almost any foreign peptide. Because the production of T cells declines with age, naive T cells must be long-lived. However, it remains unclear how naive T cells survive for years while constantly travelling. The chemoattractant sphingosine 1-phosphate (S1P) guides T cell circulation among secondary lymphoid organs, including spleen, lymph nodes and Peyer's patches, where T cells search for antigens. The concentration of S1P is higher in circulatory fluids than in lymphoid organs, and the S1P₁ receptor (S1P₁R) directs the exit of T cells from the spleen into blood, and from lymph nodes and Peyer's patches into lymph. Here we show that S1

SUBMITTER: Mendoza A 

PROVIDER: S-EPMC5683179 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature