Yeast interfering RNA larvicides targeting neural genes induce high rates of Anopheles larval mortality.

ABSTRACT:

Background

Although larviciding can reduce the number of outdoor biting malaria vector mosquitoes, which may help to prevent residual malaria transmission, the current larvicide repertoire is faced with great challenges to sustainability. The identification of new effective, economical, and biorational larvicides could facilitate maintenance and expansion of the practice of larviciding in integrated malaria vector mosquito control programmes. Interfering RNA molecules represent a novel class of larvicides with untapped potential for sustainable mosquito control. This investigation tested the hypothesis that short interfering RNA molecules can be used as mosquito larvicides.

Results

A small interfering RNA (siRNA) screen for larval lethal genes identified siRNAs corresponding

SUBMITTER: Mysore K 

PROVIDER: S-EPMC5683233 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature