Ontology highlight
ABSTRACT:
SUBMITTER: Madireddy A
PROVIDER: S-EPMC5683400 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20161001 2
Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the characteristics of CFSs that render them vulnerable to stress are associated mainly with replication, the cellular pathways that protect CFSs during replication remain unclear. Here, we identify and describe a role for FANCD2 as a trans-acting facilitator of CFS replication, in the absence of exogenous replicative stress. In the absence of FANCD2, replication forks stall within ...[more]