Immune-inflammation gene signatures in endometriosis patients.

ABSTRACT:

Objective

To determine if the molecular profiles of endometriotic lesions contain informative measures of inflammation and immune dysfunction that may contribute to better understanding of the interplay between immune dysfunction and inflammation and their contribution to endometriosis pathogenesis.

Design

Immune and inflammation transcriptomic analysis with the use of the Nanostring nCounter GX Human Immunology V2 platform (579 human immune and inflammation-related genes and 15 housekeeping genes).

Setting

Academic university and teaching hospital.

Intervention(s)

None.

Patient(s)

Stage III-IV endometriosis patients with infertility (n = 8) and fertile disease-free control women undergoing tubal ligation (n = 8). Menstrual stage was matched to secretory

SUBMITTER: Ahn SH 

PROVIDER: S-EPMC5683404 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature