Significant differences in terms of codon usage bias between bacteriophage early and late genes: a comparative genomics analysis.

ABSTRACT:

Background

Viruses undergo extensive evolutionary selection for efficient replication which effects, among others, their codon distribution. In the current study, we aimed at understanding the way evolution shapes the codon distribution in early vs. late viral genes in terms of their expression during different stages in the viral replication cycle. To this end we analyzed 14 bacteriophages and 11 human viruses with available information about the expression phases of their genes.

Results

We demonstrated evidence of selection for distinct composition of synonymous codons in early and late viral genes in 50% of the analyzed bacteriophages. Among others, this phenomenon may be related to the time specific adaptation of the viral genes to the translation efficiency factors invo

SUBMITTER: Mioduser O 

PROVIDER: S-EPMC5683454 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature