Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.

ABSTRACT:

Background

Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells.

Methods

Using more sensitive and specific transcriptome deep sequencing, we compared previously published small miRNA and long mRNA of a set of G

SUBMITTER: Oduor CI 

PROVIDER: S-EPMC5683570 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature