TERT promoter mutations are a major indicator of recurrence and death due to papillary thyroid carcinomas.

ABSTRACT:

Context

TERT promoter mutations have been associated with adverse prognosis in papillary thyroid carcinomas (PTCs).

Objective

We investigated the association between TERT promoter mutations and survival from PTC.

Design

Retrospective observational cohort study.

Patients

Eighty consecutive patients with PTC who underwent surgery between 1990 and 2003.

Measurements

TERT promoter was genotyped in DNA from 80 archival PTCs by Sanger sequencing. Median follow-up was 106 months (range 1-270). Outcomes analysis was stratified according to disease and overall survival status. For each parameter, relative risk (RR) adjusted for age at first surgery and gender was estimated. Both univariate and multivariate analyses were performed using logistic regression, Kaplan

SUBMITTER: Bullock M 

PROVIDER: S-EPMC5683578 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature