Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B.

ABSTRACT:

Objective

Amphotericin B (AMB), a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) for the treatment of fungal infections has been recently developed to provide greater protection from AMB toxicity than current, clinically approved lipid-based formulations. The objective of the current study was to evaluate the safety and potency of ND-AMB for sinonasal delivery using an in vitro model.

Methods

Human sinonasal tissue was harvested during endoscopic sinus surgery and grown at air-liquid interface until well-differentiated. Cultures were exposed to ND-AMB vs AMB and changes in K⁺ permeability and resistance were measured and

SUBMITTER: Cho DY 

PROVIDER: S-EPMC5683641 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature