Challenges in the Setup of Large-scale Next-Generation Sequencing Analysis Workflows.

ABSTRACT: While Next-Generation Sequencing (NGS) can now be considered an established analysis technology for research applications across the life sciences, the analysis workflows still require substantial bioinformatics expertise. Typical challenges include the appropriate selection of analytical software tools, the speedup of the overall procedure using HPC parallelization and acceleration technology, the development of automation strategies, data storage solutions and finally the development of methods for full exploitation of the analysis results across multiple experimental conditions. Recently, NGS has begun to expand into clinical environments, where it facilitates diagnostics enabling personalized therapeutic approaches, but is also accompanied by new technological, legal and ethical challe

SUBMITTER: Kulkarni P 

PROVIDER: S-EPMC5683667 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature