Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis.

ABSTRACT:

Objectives

Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well as their association with other measures of left ventricular decompensation and mortality.

Background

Progressive myocardial fibrosis drives the transition from hypertrophy to heart failure in aortic stenosis. Diffuse fibrosis is associated with extracellular volume expansion that is detectable by T1 mapping, whereas late gadolinium enhancement (LGE) detects replacement fibrosis.

Methods

In a prospective observational cohort study, 203 subjects (166 with aortic stenosis [69 years; 69% male]; 37 healthy volunteers [68 years; 65% male]) underwent comprehensive phenotypic characterization with clinical imaging

SUBMITTER: Chin CWL 

PROVIDER: S-EPMC5683736 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature