Retromer stops beta-arrestin 1-mediated signaling from internalized cannabinoid 2 receptors.

ABSTRACT: G protein-coupled receptors mediate their complex functions through activation of signaling cascades from receptors localized at the cell surface and endosomal compartments. These signaling pathways are modulated by heterotrimeric G proteins and the scaffold proteins beta-arrestin 1 and 2. However, in contrast to the events occurring at the cell surface, our knowledge of the mechanisms controlling signaling from receptors localized at intracellular compartments is still very limited. Here we sought to investigate the intracellular signaling from cannabinoid 2 receptor (CB₂R). First, we show that receptor internalization is required for agonist-induced phosphorylation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). Then we demonstrate that ERK1/2 activation is

SUBMITTER: Nogueras-Ortiz C 

PROVIDER: S-EPMC5683765 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature