Pre-treatment EEG signal variability is associated with treatment success in depression.

ABSTRACT:

Background

Previous work suggests that major depressive disorder (MDD) is associated with disturbances in global connectivity among brain regions, as well as local connectivity within regions. However, the relative importance of these global versus local changes for successful antidepressant treatment is unknown. We used multiscale entropy (MSE), a measure of brain signal variability, to examine how the propensity for local (fine scale MSE) versus global (coarse scale MSE) neural processing measured prior to antidepressant treatment is related to subsequent treatment response.

Methods

We collected resting-state EEG activity during eyes-open and closed conditions from unmedicated individuals with MDD prior to antidepressant pharmacotherapy (N = 36) as well as from non-depress

SUBMITTER: Jaworska N 

PROVIDER: S-EPMC5683802 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature