Susceptibility and Resilience to Posttraumatic Stress Disorder-like Behaviors in Inbred Mice.

ABSTRACT:

Background

The limited neurobiological understanding of posttraumatic stress disorder (PTSD) has been partially attributed to the need for improved animal models. Stress-enhanced fear learning (SEFL) in rodents recapitulates many PTSD-associated behaviors, including stress-susceptible and stress-resilient subgroups in outbred rats. Identification of subgroups requires additional behavioral phenotyping, a confound to mechanistic studies.

Methods

We employed a SEFL paradigm in inbred male and female C57BL/6 mice that combines acute stress with fear conditioning to precipitate traumatic-like memories. Extinction and long-term retention of extinction were examined after SEFL. Further characterization of SEFL effects on male mice was performed with additional behavioral tests, de

SUBMITTER: Sillivan SE 

PROVIDER: S-EPMC5683920 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature