Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume.

ABSTRACT:

Background

Hippocampal volume loss is a hallmark of clinical depression. Chronic stress produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells and suppression of adult neurogenesis in rodents.

Methods

To investigate the relationship between decreased adult neurogenesis and stress-induced changes in hippocampal structure and volume, we compared the effects of chronic unpredictable restraint stress and inhibition of neurogenesis in a rat pharmacogenetic model.

Results

Chronic unpredictable restraint stress over 4 weeks decreased total hippocampal volume, reflecting loss of volume in all hippocampal subfields and in both dorsal and ventral hippocampus. In contrast, complete inhibition of adult neurogenesis for 4 weeks led to volume reduction

SUBMITTER: Schoenfeld TJ 

PROVIDER: S-EPMC5683934 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature