Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite.

ABSTRACT:

Purpose

A high interindividual variability is observed in the pharmacokinetics of clopidogrel, a widely used antiplatelet drug. In the present study, a joint parent-metabolite population pharmacokinetic model was developed to adequately describe observed concentrations of clopidogrel and its active thiol metabolite (H4).

Methods

The study included 63 patients undergoing elective coronarography or percutaneous coronary intervention. The population pharmacokinetic model was developed in the NONMEM 7.3 software, and first-order conditional estimation method with interaction was applied. Also, the influence of covariates was evaluated (age, weight, body mass index (BMI), obesity defined as BMI ≥ 30 kg/m², sex, diabetes mellitus, co-administration of PPI or statins, pr

SUBMITTER: Danielak D 

PROVIDER: S-EPMC5684285 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature