Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism.

ABSTRACT: Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related gene expression does not correlate with functional oxidative measurements in the developing heart. Gene expression analysis suggests a gradual overall upregulation of oxidative-related genes and pathways, whereas functional assessment in both cardiac tissue and cultured cardiomyocytes indicated that oxidative metabolism decreases between the first and seventh days after birth. Cardiomyocyte extracellular flux analysis indicated that the decrease in oxidative metabolism between the first an

SUBMITTER: de Carvalho AETS 

PROVIDER: S-EPMC5684334 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature