Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.

ABSTRACT: The relationships between β-amyloid (Aβ), tau and neurodegeneration within Alzheimer's Disease pathogenesis are not fully understood. To explore these associations in vivo, we evaluated 30 Aβ PET-positive patients (mean ± sd age 62.4 ± 8.3) with mild probable AD and 12 Aβ PET-negative healthy controls (HC) (mean ± sd age 77.3 ± 6.9) as comparison. All participants underwent 3 T MRI, ¹¹C-PiB (Aβ) PET and ¹⁸F-AV1451 (tau) PET. Multimodal correlation analyses were run at both voxel- and region-of-interest levels. ¹¹C-PiB retention in AD showed the most diffuse uptake pattern throughout association neocortex, whereas ¹⁸F-AV1451 and gray matter volume reduction (GMR) showed a progressive predilection for posterior cortices (p<0.05 Family-Wise E

SUBMITTER: Iaccarino L 

PROVIDER: S-EPMC5684433 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature