Gray matter atrophy patterns in multiple sclerosis: A 10-year source-based morphometry study.

ABSTRACT:

Objectives

To investigate spatial patterns of gray matter (GM) atrophy and their association with disability progression in patients with early relapsing-remitting multiple sclerosis (MS) in a longitudinal setting.

Methods

Brain MRI and clinical neurological assessments were obtained in 152 MS patients at baseline and after 10 years of follow-up. Patients were classified into those with confirmed disability progression (CDP) (n = 85) and those without CDP (n = 67) at the end of the study. An optimized, longitudinal source-based morphometry (SBM) pipeline, which utilizes independent component analysis, was used to identify eight spatial patterns of common GM volume co-variation in a data-driven manner. GM volume at baseline and rates of change were compared betw

SUBMITTER: Bergsland N 

PROVIDER: S-EPMC5684496 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature