Genetic and Clinical Characteristics of Phyllodes Tumors of the Breast.

ABSTRACT:

Purpose

Phyllodes tumors (PTs) of the breast are rare, accounting for less than 1% of all breast tumors. Among PTs, malignant PTs (MPTs) have malignant characteristics and distant metastases occur in about 20% to 30% of MPTs. However, there is no effective treatment for MPTs with distant metastasis, resulting in an abject prognosis. We performed targeted deep sequencing on PTs to identify the associations between genetic alterations and clinical prognosis.

Methods

We performed targeted deep sequencing to evaluate the genetic characteristics of PTs and analyzed the relationships between clinical and genetic characteristics.

Results

A total of 17 PTs were collected between 2001 and 2012. Histologic review was performed by pathologists. The samples included three benign

SUBMITTER: Kim JY 

PROVIDER: S-EPMC5684533 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature