Evaluation of factors influencing ¹⁸F-FET uptake in the brain.

ABSTRACT: PET using the amino-acid O-(2-¹⁸F-fluoroethyl)-l-tyrosine (¹⁸F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of ¹⁸F-FET uptake in various brain areas, and thus affect quantification of ¹⁸F-FET uptake in brain tumours. Negative ¹⁸F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of ¹⁸F-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and vo

SUBMITTER: Verger A 

PROVIDER: S-EPMC5684535 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature