Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions.

ABSTRACT: The science behind psychotherapy has garnered considerable interest, as objective measures are being developed to map the patient's subjective change over the course of treatment. Prenatal and early life influences have a lasting impact on how genes are expressed and the manner in which neural circuits are consolidated. Transgenerationally transmitted epigenetic markers as well as templates of enhanced thought flexibility versus evasion can be passed down from parent to child. This influences gene expression/repression (impacting neuroplasticity) and kindling of neurocircuitry which can perpetuate maladaptive cognitive processing seen in a number of psychiatric conditions. Importantly, genetic factors and the compounding effects of early life adversity do not inexorably lead to certain fat

SUBMITTER: Miller CWT 

PROVIDER: S-EPMC5684598 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature