Lactate Metabolism in Human Lung Tumors.

ABSTRACT: Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle. Here, we show that lactate is also a TCA cycle carbon source for NSCLC. In human NSCLC, evidence of lactate utilization was most apparent in tumors with high ¹⁸fluorodeoxyglucose uptake and aggressive oncological behavior. Infusing human NSCLC patients with ¹³C-lactate revealed extensive labeling of TCA cycle metabolites. In mice, deleting monocarboxylate transporter-1 (MCT1) from tumor cells eliminated lactate-dependent metabolite labeling, confirming tumor-cell-autonomous lactate uptake. Strikingly, dir

SUBMITTER: Faubert B 

PROVIDER: S-EPMC5684706 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature