Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment.

ABSTRACT:

Background

Colonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C. difficile is desirable because diagnostic and therapeutic strategies based on the human microbiota have the potential to provide more precision to the management and treatment of Clostridium difficile infection (CDI) and its recurrence.

Methods

We conducted a longitudinal study of adult patients diagnosed with their first CDI. We investigated the dynamics of the gut microbiota during antibiotic treatment, and we used microbial or demographic features at the time of diagnosis, or after treatment, to predict CDI recurrence. To check the validity of the predictions, a meta-analysis

SUBMITTER: Pakpour S 

PROVIDER: S-EPMC5684761 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature