Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli.

ABSTRACT:

Background

Developing innovative drugs with potent efficacy, specificity, and high safety remains an ongoing task in antitumor therapy development. In the last few years, peptide drugs have become attractive agents in cancer therapy. HM-3, mainly with antiangiogenic effect, and AP25, with an additional antiproliferative effect, are two peptides designed in our laboratory targeting α_vβ₃ and α₅β₁ integrins, respectively. The low molecular weight of the two peptides renders their recombinant expression very difficult, and the complicated structure of AP25 makes its chemical synthesis restricted, which presents a big challenge for its development.

Methods

Bifunctional peptides designed by the ligation of HM-3 and AP25, using linkers wi

SUBMITTER: Setrerrahmane S 

PROVIDER: S-EPMC5685134 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature