Removal of Differential Capacitive Interferences in Fast-Scan Cyclic Voltammetry.

ABSTRACT: Due to its high spatiotemporal resolution, fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes enables the localized in vivo monitoring of subsecond fluctuations in electroactive neurotransmitter concentrations. In practice, resolution of the analytical signal relies on digital background subtraction for removal of the large current due to charging of the electrical double layer as well as surface faradaic reactions. However, fluctuations in this background current often occur with changes in the electrode state or ionic environment, leading to nonspecific contributions to the FSCV data that confound data analysis. Here, we both explore the origin of such shifts seen with local changes in cations and develop a model to account for their shape. Further, we describe a convolu

SUBMITTER: Johnson JA 

PROVIDER: S-EPMC5685151 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature