Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer.

ABSTRACT: Despite the known importance of androgen receptor (AR) signaling in prostate cancer, the processes downstream of AR that drive disease development and progression remain poorly understood. This knowledge gap has thus limited the ability to treat cancer. Here, it is demonstrated that androgens increase the metabolism of glutamine in prostate cancer cells. This metabolism was required for maximal cell growth under conditions of serum starvation. Mechanistically, AR signaling promoted glutamine metabolism by increasing the expression of the glutamine transporters SLC1A4 and SLC1A5, genes commonly overexpressed in prostate cancer. Correspondingly, gene expression signatures of AR activity correlated with SLC1A4 and SLC1A5 mRNA levels in clinical cohorts. Interesting

SUBMITTER: White MA 

PROVIDER: S-EPMC5685160 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature