Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens.

ABSTRACT: The subdifferentiation of the nucleus accumbens (NAc) has been extensively studied using neuroanatomy and histochemistry, yielding a well-accepted dichotomic shell/core architecture that reflects dissociable roles, such as in reward and aversion, respectively. However, in vivo parcellation of these structures in humans has been rare, potentially impairing future research into the structural and functional characteristics and alterations of putative NAc subregions. Here, we used three complementary parcellation schemes based on tractography, task-independent functional connectivity, and task-dependent co-activation to investigate the regional differentiation within the NAc. We found that a 2-cluster solution with shell-like and core-like subdivisions provided the best description of the dat

SUBMITTER: Xia X 

PROVIDER: S-EPMC5685173 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature