A perspective for sequencing familial hypercholesterolaemia in African Americans.

ABSTRACT: African Americans suffer disproportionately from poor cardiovascular health outcomes despite similar proportions of African Americans and Americans of European ancestry experiencing elevated cholesterol levels. Some of the variation in cardiovascular outcomes is due to confounding effects of other risk factors, such as hypertension and genetic influence. However, genetic variants found to contribute to variation in serum cholesterol levels in populations of European ancestry are less likely to replicate in populations of African ancestry. To date, there has been limited follow-up on variant discrepancies or on identifying variants that exist in populations of African ancestry. African and African-American populations have the highest levels of genetic heterogeneity, which is a factor that

SUBMITTER: Wright ML 

PROVIDER: S-EPMC5685298 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature