Pathogenic landscape of idiopathic male infertility: new insight towards its regulatory networks.

ABSTRACT: Idiopathic male infertility (IMI) affects nearly 10-15% of men in their prime reproductive age. More than 500 target genes were postulated to be associated with this disease condition through various genomic studies. The challenge is to determine the functional role of these genes and proteins that form part of a larger network leading to pathogenesis of the IMI phenotype in humans. In the current study, we have catalogued all of the genes associated with IMI from published studies, as well as looked at reactive oxygen species and antioxidant genes, the two key physiological determinants essential for normal spermatogenesis. Any imbalance in these genes through mutation, single-nucleotide polymorphisms (SNPs) or other forms could result in abnormal regulation of genes leading to infertilit

SUBMITTER: Kothandaraman N 

PROVIDER: S-EPMC5685305 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature