Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease.

ABSTRACT: Ankylosing spondylitis (AS) is a common chronic immune-mediated arthropathy affecting primarily the spine and pelvis. The condition is strongly associated with HLA-B*27 as well as other human leukocyte antigen variants and at least 47 individual non-MHC-associated variants. However, substantial additional heritability remains as yet unexplained. To identify further genetic variants associated with the disease, we undertook an association study of AS in 5,040 patients and 21,133 healthy controls using the Illumina Exomechip microarray. A novel association achieving genome-wide significance was noted at CDKAL1. Suggestive associations were demonstrated with common variants in FAM118A, C7orf72 and FAM114A1 and with a low-frequency variant in PNPLA1. T

SUBMITTER: Robinson PC 

PROVIDER: S-EPMC5685324 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature