Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain.

ABSTRACT: Although it has been believed that the evolution of cortical folds was a milestone, allowing for an increase in the number of neurons in the cerebral cortex, the mechanisms underlying the formation of cortical folds are largely unknown. Here we show regional differences in the expression of fibroblast growth factor receptors (FGFRs) in the developing cerebral cortex of ferrets even before cortical folds are formed. By taking the advantage of our in utero electroporation technique for ferrets, we found that cortical folding was impaired in the ferret cerebral cortex when FGF signaling was inhibited. We also found that FGF signaling was crucial for producing Pax6-positive neural progenitors in the outer subventricular zone (OSVZ) of the developing cerebral cortex. Furthermore, we foun

SUBMITTER: Matsumoto N 

PROVIDER: S-EPMC5685484 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature