Ontology highlight
ABSTRACT:
SUBMITTER: Torzewski M
PROVIDER: S-EPMC5685511 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Torzewski Michael M Ravandi Amir A Yeang Calvin C Edel Andrea A Bhindi Rahul R Kath Stefan S Twardowski Laura L Schmid Jens J Yang Xiaohong X Franke Ulrich F W UFW Witztum Joseph L JL Tsimikas Sotirios S
JACC. Basic to translational science 20170626 3
The <i>LPA</i> gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets were categorized pathologically from Both ATX-apoB and ATX-apo(a) were measureable in plasma. Lp(a), autotaxin, OxPL and MDA epitopes progressively increased in immunostaining (p<0.001 for all). Six species of OxPL and LysoPA were identified following extraction ...[more]