Ontology highlight
ABSTRACT:
SUBMITTER: Belinson H
PROVIDER: S-EPMC5685528 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Belinson H H Nakatani J J Babineau B A BA Birnbaum R Y RY Ellegood J J Bershteyn M M McEvilly R J RJ Long J M JM Willert K K Klein O D OD Ahituv N N Lerch J P JP Rosenfeld M G MG Wynshaw-Boris A A
Molecular psychiatry 20160202 10
Social interaction is a fundamental behavior in all animal species, but the developmental timing of the social neural circuit formation and the cellular and molecular mechanisms governing its formation are poorly understood. We generated a mouse model with mutations in two Disheveled genes, Dvl1 and Dvl3, that displays adult social and repetitive behavioral abnormalities associated with transient embryonic brain enlargement during deep layer cortical neuron formation. These phenotypes were media ...[more]