Association between Haemagglutination inhibiting antibodies and protection against clade 6B viruses in 2013 and 2015.

ABSTRACT:

Background

The epidemiology of the pandemic A(H1N1) virus has been changing as population immunity continues to co-evolve with the virus. The impact of genetic changes in the virus on human's susceptibility is an outstanding important question in vaccine design. In a community-based study, we aim to (1) determine the genetic characteristics of 2009-2015 pandemic H1N1 viruses, (2) assess antibody response following natural infections and (3) assess the correlation of A/California/07/09 antibody titers to protection in the 2013 and 2015 epidemics.

Methods

In a household transmission study, serum specimens from 253 individuals in Managua, Nicaragua were analyzed. Combined nose and throat swabs were collected to detect RT-PCR confirmed influenza infection and virus sequencing. H

SUBMITTER: Ng S 

PROVIDER: S-EPMC5685664 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature