Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring.

ABSTRACT:

Objectives

We sought to define the lower and upper limits of cerebral blood flow autoregulation and the optimal blood pressure during cardiopulmonary bypass. We further sought to identify variables predictive of these autoregulation end points.

Methods

Cerebral autoregulation was monitored continuously with transcranial Doppler in 614 patients during cardiopulmonary bypass enrolled in 3 investigations. A moving Pearson's correlation coefficient was calculated between cerebral blood flow velocity and mean arterial pressure to generate the variable mean velocity index. Optimal mean arterial pressure was defined as the mean arterial pressure with the lowest mean velocity index indicating the best autoregulation. The lower and upper limits of cerebral blood flow autoregulation w

SUBMITTER: Hori D 

PROVIDER: S-EPMC5685671 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature