Inhibition of autoimmune Th17 cell responses by pain killer ketamine.

ABSTRACT: Ketamine is widely used in animals and humans as a systemic anesthetic. Although several immune-modulatory functions of ketamine have been reported, the effects of ketamine on the differentiation of Th17 cell are unknown. We found that ketamine significantly diminished the frequency of IL-17-producers among CD4⁺ T cells stimulated under Th17-skewing conditions. Mechanistic studies showed that ketamine had little effect on the production of Th17-inducing cytokines by dendritic cells and the proliferation of T cells in response to anti-CD3; however it significantly hampered IL-21 expression as well as STAT3 phosphorylation in T cells upon IL-6 stimulation. Moreover, MOG-reactive CD4⁺ T cells expanded in the presence of ketamine produced reduced amounts of Th17 cytokines

SUBMITTER: Lee JE 

PROVIDER: S-EPMC5685685 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature