CD4⁺T cell specific B7-H1 selectively inhibits proliferation of naive T cells and Th17 differentiation in experimental autoimmune encephalomyelitis.

ABSTRACT: It is widely acknowledged that interleukin 17-producing T helper (Th17) cells are critically participant in the pathogenesis of multiple sclerosis. In the current study, we identified that the expression of CD4⁺T cells specific co-inhibitory molecule B7-homologue 1(B7-H1) in spleenocytes and mononuclear cells isolated from brains and spinal cord were positive correlated with Th1 and Th17 cells generation and disease severity in experimental autoimmune encephalomyelitis (EAE). Furthermore, B7-H1 transgenic mice developed milder EAE symptoms and fewer Th17 cells than B7-H1 wild type mice. We also found the proliferation of naïve CD4⁺CD62⁺T cells isolated from B7-H1 transgenic mice was inhibited. And naïve T cells isolated from B7-H1 transgenic mice produced f

SUBMITTER: Shi SJ 

PROVIDER: S-EPMC5685729 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature