The clinical use of circulating microRNAs as non-invasive diagnostic biomarkers for lung cancers.

ABSTRACT: Many studies have investigated the diagnostic role of circulating microRNAs (miRNAs) in patients with lung cancer; however, the results still remain inconclusive. An updated system review and meta-analysis was necessary to give a comprehensive evaluation of diagnostic role of circulating miRNAs in lung cancer. Eligible studies were searched in electronical databases. The sensitivity and specificity were used to plot the summary receiver operator characteristic (SROC) curve and calculate the area under the curve (AUC). The between-study heterogeneity was evaluated by Q test and I² statistics. Subgroup analyses and meta-regression were further performed to explore the potential sources of heterogeneity. A total of 134 studies from 65 articles (6,919 patients with lung cancer and 7

SUBMITTER: Yang Y 

PROVIDER: S-EPMC5685742 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature