Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder.

ABSTRACT: Lithium is the most commonly prescribed medication for the treatment of bipolar disorder (BD), yet the mechanisms underlying its beneficial effects are still unclear. We aimed to compare the effects of lithium treatment in lymphoblastoid cell lines (LCLs) from BD patients and controls. LCLs were generated from sixty-two BD patients (based on DSM-IV) and seventeen healthy controls matched for age, sex, and ethnicity. Patients were recruited from outpatient clinics from February 2012 to October 2014. LCLs were treated with 1mM lithium for 7 days followed by microarray gene expression assay and validation by real-time quantitative PCR. Baseline differences between groups, as well as differences between vehicle- and lithium-treated cells within each group were analyzed. The biological signific

SUBMITTER: Fries GR 

PROVIDER: S-EPMC5685885 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature