Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor.

ABSTRACT: Rodents are characterized by continuously renewing incisors whose growth is fueled by epithelial and mesenchymal stem cells housed in the proximal compartments of the tooth. The epithelial stem cells reside in structures known as the labial (toward the lip) and lingual (toward the tongue) cervical loops (laCL and liCL, respectively). An important feature of the rodent incisor is that enamel, the outer, highly mineralized layer, is asymmetrically distributed, because it is normally generated by the laCL but not the liCL. Here, we show that epithelial-specific deletion of the transcription factor Islet1 (Isl1) is sufficient to drive formation of ectopic enamel by the liCL stem cells, and also that it leads to production of altered enamel on the labial surface. Molecular analyses of developin

SUBMITTER: Naveau A 

PROVIDER: S-EPMC5685895 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature