Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming.

ABSTRACT:

Objective

Cinnamaldehyde (CA) is a food compound that has previously been observed to be protective against obesity and hyperglycemia in mouse models. In this study, we aimed to elucidate the mechanisms behind this protective effect by assessing the cell-autonomous response of primary adipocytes to CA treatment.

Methods

Primary murine adipocytes were treated with CA and thermogenic and metabolic responses were assessed after both acute and chronic treatments. Human adipose stem cells were differentiated and treated with CA to assess whether the CA-mediated signaling is conserved in humans.

Results

CA significantly activated PKA signaling, increased expression levels of thermogenic genes and induced phosphorylation of HSL and PLIN1 in murine primary adipocytes. Inhibit

SUBMITTER: Jiang J 

PROVIDER: S-EPMC5685898 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature