Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic, or associated with other conditions. Circulating autoantibodies, lung perivascular lymphoid tissue, and elevated cytokines have been related to PAH pathogenesis but without a clear understanding of how these abnormalities are initiated, perpetuated, and connected in the progression of disease. We therefore set out to identify specific target antigens in PAH lung immune complexes as a starting point toward resolving these issues to better inform future application of immunomodulatory therapies.

Methods

Lung immune complexes were isolated and PAH target antigens were identified by liquid chromatography tandem mass spectrometr

SUBMITTER: Saito T 

PROVIDER: S-EPMC5685911 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature