Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

ABSTRACT: Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxide synthase (NOS)2, the prototype markers for alternative or classical macrophage activation, respectively. Because both enzymes are antipodean macrophage effector molecules in Mycobacterium tuberculosis (Mtb) infection, we assessed the relevance of SOCS3 for macrophage activation during experimental tuberculosis using macrophage-specific SOCS3-deficient (LysM^creSOCS3^loxP/loxP) mice. Aerosol infection of LysM^creSOCS3^loxP/loxP mice resulted in remarkably higher bacterial loads in infected

SUBMITTER: Schmok E 

PROVIDER: S-EPMC5686055 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature