New Multiple Sclerosis Disease Severity Scale Predicts Future Accumulation of Disability.

ABSTRACT: The search for the genetic foundation of multiple sclerosis (MS) severity remains elusive. It is, in fact, controversial whether MS severity is a stable feature that predicts future disability progression. If MS severity is not stable, it is unlikely that genotype decisively determines disability progression. An alternative explanation tested here is that the apparent instability of MS severity is caused by inaccuracies of its current measurement. We applied statistical learning techniques to a 902 patient-years longitudinal cohort of MS patients, divided into training (n = 133) and validation (n = 68) sub-cohorts, to test four hypotheses: (1) there is intra-individual stability in the rate of accumulation of MS-related disability, which is also influenced by extrinsic factor

SUBMITTER: Weideman AM 

PROVIDER: S-EPMC5686060 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature